How to remove a tool from all players' backpack??

Iterate through all the Players' backpacks and Remove their tools.

local function removeTools()
    local players = game.Players:GetPlayers() -- Table of all players in the game
    for _, player in pairs(players) do -- Use a for loop to iterate through the players table
        local backpack = player:FindFirstChild("Backpack") -- Locate the backpack
        if backpack then -- If the backpack was succesfully found...
            backpack:ClearAllChildren() -- Remove everything from their Backpack
        end
    end
end


removeTools()

This code should work...

local player = game.Players:GetPlayers()
local backpack = player:WaitForChild("Backpack") 
local character = player.Character or player.CharacterAdded:Wait()

local Itemstodestory = {"TOOL1", "TOOL2", "TOOL3", "TOOL4", "TOOL5"}

local function Desteoyfunction(tools)
    for _, launcher in pairs(Itemstodestory) do
        local tool = tools:FindFirstChild(Desteoyfunction)
        if tool and tool:IsA("Tool") then
            tool:Destroy()
        end
    end
end

Desteoyfunction  (backpack)
Desteoyfunction  (character)

if you want to clear the children of the tools then do this

for _,v in pairs(game.Players:GetPlayers()) do
    v.Backpack:ClearAllChildren() 
end

This should work:

for _,v in pairs(game.Players:GetPlayers()) do
local bp = v:FindFirstChild("Backpack")
if bp then
bp:ClearAllChildren()
end
end

If the Item is equiped:

for _,w in pairs(game.workspace:GetDescendants()) do
if w:IsA("Tool") and game.Players:FindFirstChild(w.Parent.Name) then
w:Destroy()
end