How the heck do I teleport an NPC in the Workspace somewhere?

Using the Humanoid for :MoveTo(), I wouldn't use as it causes it to walk instead of actually teleport. Instead, target the Model. As it will provide the PrimaryPart, which should be the Instance passed to teleporting

So to solve your issue, this is what your Script should look like

local CoordianteFrame = workspace:WaitForChild("Location1").CFrame
local UserInputService = game:GetService("UserInputService") --// Random Event fire.
local Char = workspace:WaitForChild("NPC")
UserInputService.InputBegan:Connect(function(InputObject, GameProcessed)
    pcall(function()
        if (InputObject.KeyCode == Enum.KeyCode.E and not GameProcessed) then
            if (Char:FindFirstChild("Humanoid"):IsA("Humanoid")) then --// Same principles
                Char:MoveTo(CoordianteFrame.Position)
                return
            end
            print(Char.Name.." doesn't have a Humanoid.")
        end
    end)
end)

Hope this sends you in the right direction, I suggest reading about :MoveTo() to get a better grasp, also UserInputService may be new to you, so check out UserInputSerivce when you can. Good Luck! lots have changed in this past year.

To teleport something with a humanoid, you need to change the CFrame value.

workspace.NPC.PrimaryPart.CFrame = CFrame.new(x, y, z)

x, y, and z are the coordinates of the destination.

Hope this helps