Why is the Condition in my If statement not being recognized?

First of all, you should use code blocks. Like aazkao said, you need to put the code in between the ~~ lines after you click the blue Lua button.

Also, when you're defining a variable and won't use it elsewhere, you should put a local before it. You might not get what I mean by elsewhere, but you could always check the wiki to know what local variables and global variables are. But for now, basically when you're defining a variable outside of any function or statement, you use local.

local Part = script.Parent -- the local goes before the variable

Part.Touched:Connect(function(hit) wait(0.5) Part.Anchored = false end)

if Part.Anchored == false then
    print("Worked")
    wait(2)
    Parte = Instance.new("Part", game.Workspace)
    Parte.Anchored = true
    Parte.Position = Vector3.new(-22, 1, 4)
end

Now, why this isn't working? A script goes from top to bottom extremely fast. the if statement of yours won't work as when the if statement is called, the Part's Anchored property is not false.

In other words, the if statement is being called before the function that's supposed to make the Part's property to false is called.

To fix this, you can use a wait statement to wait a few seconds before calling the if statement.

local Part = script.Parent

Part.Touched:Connect(function(hit) wait(0.5) Part.Anchored = false end)

wait(3) -- waits 3 seconds

if Part.Anchored == false then
    print("Worked")
    wait(2)
    Parte = Instance.new("Part", game.Workspace)
    Parte.Anchored = true
    Parte.Position = Vector3.new(-22, 1, 4)
end

This will wait 3 seconds before the if statement is called, therefore it will only print "Worked" if the Part's Anchored property is false after the script is ran.

You could also put it inside of a function and call that function when you want to. (Like the OnTouched event is only called when its part is touched.) Here's an example:

local Part = script.Parent
local CD = Part:WaitForChild("ClickDetector") -- it waits until it finds "ClickDetector" inside of *Part*.

Part.Touched:Connect(function(hit) wait(0.5) Part.Anchored = false end)

CD.MouseClick:Connect(function() -- fires when CD (the ClickDetector) is clicked by a player.
    if Part.Anchored == false then
        print("Worked")
        wait(2)
        Parte = Instance.new("Part", game.Workspace)
        Parte.Anchored = true
        Parte.Position = Vector3.new(-22, 1, 4)
    end
end)

In this example, there is a ClickDetector inside of Part. The script waits until it finds "ClickDetector" inside of Part. When the ClickDetector is clicked, it will fire a function that has your if statement in. When the Part's Anchored property is true when you click on the ClickDetector, it will print ("Worked").

I hope this helped in any way, I'm really not a good explainer. Thanks for reading.