Round Simulation. Loops or Otherwise?

I want to put players in a continuous round simulation. I have a number of functions listed, and then with those functions I can put them in a loop. The question I have is, do I even use a loop for such a thing? (A loop meaning a 'while true do' loop. ) Do most developers, such as those of Mad Murderer, Paintball, Slender Stop It, Murder Mystery, etc. use while true do loops to run their entire round simulated games?