Is it more efficient to instantiate objects in script or in Studio through Explorer?

I feel that the answer to the question would depend on the situation, but, I am hoping that someone can provide me (and others who may look at this question) a good explanation into efficient scripting.

Also, to clarify what I mean by "efficient", I mean it in many ways, but the primary standards being: -Hogging less resources -Runs faster with the least amount of function calls I mean, if I make stuff on the Explorer, it seems like I am putting in less lines of code, but because functions here are sometimes covered with syntactic sugar (and plus, I don't know how efficiently ROBLOX instantiates something already put into say, game.ReplicatedStorage), I really don't have a solid clue which one would be more efficient.

Here are two situations:

Would doing this in a Script...

local event = Instance.new("RemoteEvent", game.ReplicatedStorage)

...be more efficient than putting a RemoteEvent in ReplicatedStorage through the Explorer in Roblox Studio so that instead I can do...

local event = game.ReplicatedStorage.RemoteEvent

Or for instance, in a gun tool, would it be more efficient to instantiate a bullet in the script like...

local bullet= Instance.new('Part') do
bullet.Name = 'Rocket'
bullet.FormFactor = Enum.FormFactor.Custom 
bullet.Size = ROCKET_PART_SIZE
bullet.CanCollide = false

...or put in a bullet in the tool (or some other location) through the Explorer in Roblox Studio and make the local variable bullet reference like...

local bullet= script.Parent.bullet