Is calling a function inside of a while loop a good choice?

I have called functions in loops many times and I was wondering if it the right method?

I believe that this is a poor way of calling a function from a loop:

local function run(number)
    if (number == 1) then
    print("the number is " .. number)
end

while script.Parent.Disabled == false do
    local randomNum = math.random(1, 4)
    wait()
    run(randomNum)
end

I have done this before but I am not sure if it is reliable enough to use in a popular published game:

functionRunning= false

local function run(number)
    functionRunning = true

    if (number == 1) then
    print("the number is " .. number)

    functionRunning = false
end

while loopRunning == false do
    local randomNum = math.random(1, 4)
    wait()
    run(randomNum)
end

Please let me know if there is any better way to call a function repeatedly from a loop. I have real code (not just examples) if that is needed to find the answer to this question please let me know and I could also post that here.