Non-Clickable GUI button in-game but works in Studio?

I've got a tool and inside I have a local script, which has a function that fires when a button is clicked on a GUI (The GUI pops up when the tool is equipped). This works perfectly fine in studio, No outputs - works as it should. But in-game is a totally different error - I can't even click the button for the function to fire?

wait(2)

frame= script.Parent.Frame.ScrollingFrame
plr = game.Players.LocalPlayer
frame.Finish.MouseButton1Down:connect(function()
    if script.Parent.Done.Value == false and game.ServerStorage:FindFirstChild(plr.Name) == nil then
        script.Parent.Done.Value = true
        frame.Finish:Destroy()
        frame.Questions:Destroy()
        frame.Name = game.Players.LocalPlayer.Name
        frame.Visible = false
        frame.Header.Text = game.Players.LocalPlayer.Name

        if game.Workspace.ApplicationMachine.Computer.Screen.Gui.Frame.Main.AppNames.Empty1.Value.Value == false then
                game.Workspace.ApplicationMachine.Computer.Screen.Gui.Frame.Main.AppNames.Empty1.Value.Value = true
                frame.Parent = game.Workspace.ApplicationMachine.Computer.Screen.Gui.Frame.Main.AppNames.Empty1 
                game.Workspace.ApplicationMachine.Computer.Screen.Gui.Frame.Main.AppNames.Empty1.Text = (plr.Name).."'s Application"

There is more of this script (Over 100 lines total) But I have a feeling it's something to do with the start of it..