GUI's help?

Is there a method to check if part of an image in an Image Button or Image Label (excluding the background) is touching the boundary of another GUI?

In my game, I have various sprites that I use. The box that the original sprites are all the same size (The background they are placed in is the same size for every sprite), but is there a way to detect the overlap of the image with another GUI, or do I have to create a position for each sprite to be placed on the screen? And are there any specific procedures to go by?

If any further explanation is needed, please let me know.