How do I get a part to point at another position without using CFrame's Second parameter?

So I know you can get a part's lookvector to face a certain position

But I was wondering how I could get it to point without using cframe's second parameter

By that I mean this

Part.CFrame = CFrame.new(Part.Position, Vector3.new(000,000,000) ) 

Without doing that

How would I get a lookvector facing to a position