Is it possible to use SetPrimaryPartCFrame with TweenService?

You would need to do something along these lines, however keep in mind that using SetPrimaryPartCFrame will cause floating point precision errors over time.

local tweenService = game:GetService("TweenService")
local info = TweenInfo.new()

local function tweenModel(model, CF)
	local CFrameValue = Instance.new("CFrameValue")
	CFrameValue.Value = model:GetPrimaryPartCFrame()

	CFrameValue:GetPropertyChangedSignal("Value"):Connect(function()
		model:SetPrimaryPartCFrame(CFrameValue.Value)
	end)
	
	local tween = tweenService:Create(CFrameValue, info, {Value = CF})
	tween:Play()
	
	tween.Completed:Connect(function()
		CFrameValue:Destroy()
	end)
end