I think the title is pretty self-explanatory. When do you use data persistence and data store and what is the difference between those two? Also, I searched in the tab and this hasn't been mentioned before as far as I've seen.
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Difference between datastore and data persistance?
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Data persistence is deprecated, and was introduced many years ago. DataStores were introduced in 2014.
Data persistence should never be used, and has experienced severe issues with data loss in the past. If there's something you need to use Data Persistence for that DataStores can't do, you're trying to do what you want to do in the wrong way.
For saving instances in DataStores, serialize the important data into a table and use that.
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Don't use data persistence. It is deprecated and data stores can do so much more.