Can having two identicle GUIs cause problems?

I'm having a very strange issue. I have a GUI which a script calls to open. This works fine, it opens with no issue when a part is touched. However, once I duplicate this, the part, script, and GUI, it starts to become very buggy. The GUI will flash on and off while touching the part, not staying up. This continues to happen even when changing the name of the part, gui, and script.

However, there's a different GUI that looks different and is set up differently but is in the same location with the same script setup that works even with the other GUI there.

So are there any bugs that can happen when 2 GUIs that look identical are in the game? or like what else may I be overlooking that is causing this issue?