Is there any advantage in using JSONEncode when saving to a datastore?

Does encoding a table before saving it into a datastore make the save more efficient space wise?

I recently asked a question similar to the one you are posting and thought I would tell you what I learned. The person who answered my question said that roblox already uses JSONEncoding. You will really only need it when posting data onto a different website. So the main answer to your question is no. It would be pointless. Hope this helps have a great day scripting!