How can you get clickdetector's MouseClick function to work with FilteringEnabled?

Yea, I just started learning FE and it is confusing at first, but you'll get it with practice.

So, with FE enabled, the game is practically in two (or how I view it), the server (What everyone else sees) and the client (What the player sees). In your case, you're wanting the player to click a brick or click one of the bricks in a group of bricks to do something.

So if this was one brick, you would do:

-- Client Side, could be placed in StarterPlayerScripts
game.Workspace.ClickThis.ClickDetector.MouseButton1Click:connect(function() -- event
game.ReplicatedStorage.Event:FireServer() -- Client to Server, so you FireServer()(Event=RemoteE)
end)

-- Server Side, could be placed inside your ClickDetector or ServerScriptService
game.ReplicatedStorage.Event.OnServerEvent:connect(function() -- So when Event is fired/called
	-- Stuff you want done. Remeber, this will change stuff on the server-side not locally
end)

Multiple Bricks would be the same exact thing, but you'd create a table with 'in pairs' and the bricks need to be in a model:

for i,v in pairs (game.Workspace.Model:GetChildren()) do -- gets all the children of the model
	v.ClickDetector.MouseButton1Click:connect(function() -- each brick has a clickDetector
		game.ReplicatedStorage.Event:FireServer()
	end)
end